TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis
Summary: TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is implicated in myeloid malignancies with deletion of chromosome 5q.Employing a combination of proteomic and genetic approaches, we find that TIFAB regulates ubiquitin-specific peptidase 15 click here (USP15) ubiquitin hydrolase activity.Expression of TIFAB in hematopoie